TITLE : Identify the impact of TGF - ß signaling on the stroma in the progression of prostate cancer

XWH - 04 - 1 - 0046 TITLE : Identify the Impact of TGF - ß Signaling on the Stroma in the Progression of Prostate Cancer

XWH - 04 - 1 - 0046 TITLE : Identify the impact of TGF - ß signaling on the stroma in the progression of prostate cancer PRINCIPAL INVESTIGATOR : Neil

• Placencio, V.R., Sharif-Afshar, A.-R., Simon W. Hayward, and Bhowmick N.A. (2005) Prostatic Epithelial Transformation and Androgen Responsiveness Regulated by Stromal-Epithelial Interactions. (oral presentation) Society For Basic Urologic Research Meeting. Miami, FL. Awards received based on work supported by this grant None Products CDNA construct, cell lines, and animal models developed • D...

Effects of fibromodulin protein expression on NFkB and TGFβ signaling pathways in liver cancer cells

Introduction: The incidence rate of liver cancer is continuously increasing. Currently, gene therapy is applied to improve various medical issues such as cancer treatment approaches. Correspondingly, fibromodulin involves in many biological and physiological processes through interaction with growth factors and signaling pathway receptors. The aim of this study was to investigate the effects of...

ارزیابی اثرات کوئرستین بر پروتئین های سیگنالی pSTAT3، pERK1/2، pAKT و بیان ژن اینترلوکین-6 (IL-6) در رده سلول های سرطانی پروستات PC3

Background and purpose: Interleukin-6 (IL-6) causes the progression of prostate cancer through pSTAT3, pERK1/2, and pAKT cell signaling proteins. Quercetin, an herbal antioxidant, has anti-tumor effect. The aim of this study was to evaluate the effects of quercetin on IL-6 gene expression, and the above cellular signaling proteins in PC3 prostate cancer cells. Materials and methods: In this ...

The Role of Cyclooxygenase-2 in Signaling Pathways Promoting Colorectal Cancer

Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been ...